Clascoterone Cream 1% : the Next Generation of Acne Therapeutics

Hey Skincare Squaddies!

Get ready to flip your skincare routine upside down because we've got the inside scoop on the latest breakout star – Clascoterone Cream, 1%! 🌟

Imagine a cream so good, it's like your skin's personal superhero against acne. We're decoding the results of a TWO Phase 3 Randomized Clinical Trials, showcasing the proven efficacy and safety of Clascoterone Cream for treating facial acne.

Think of it as the skincare equivalent of a mic drop. 🎤✨

In this edition, we're unpacking the insights from a key research paper: "Efficacy and Safety of Topical Clascoterone Cream, 1%, for Treatment in Patients With Facial Acne."

The study was published in June 2020 in journal JAMA dermatology.

Acne is a common skin condition that affects millions of people worldwide, especially adolescents and young adults. It can cause physical and psychological distress, as well as scarring and infection. Current treatments for acne include topical and oral medications, such as antibiotics, retinoids, and hormonal agents, but they may have limited efficacy or undesirable side effects.

A new topical cream, clascoterone, may offer a novel and safe alternative for acne treatment.

Clascoterone is a synthetic androgen receptor inhibitor that works by blocking the effects of dihydrotestosterone (DHT), a hormone that stimulates sebum production and inflammation in the skin.

Two phase 3 randomized clinical trials, conducted by Hebert et al, evaluated the efficacy and safety of clascoterone cream, 1%, compared with vehicle cream in patients with facial acne. The trials enrolled a total of 1440 patients aged 9 years or older with moderate to severe acne, who applied clascoterone or vehicle cream twice daily for 12 weeks.

The results showed that clascoterone cream, 1%, was significantly more effective than vehicle cream in reducing the number of inflammatory and noninflammatory lesions, as well as achieving treatment success, defined as clear or almost clear skin.

Clascoterone cream, 1%, was also well tolerated, with no serious adverse events or systemic absorption reported.

The authors concluded that clascoterone cream, 1%, is a promising new topical therapy for acne that targets the androgen receptor pathway, without causing hormonal imbalance or systemic side effects.

They suggested that clascoterone cream, 1%, could be used as monotherapy or in combination with other acne treatments, such as benzoyl peroxide or antibiotics.

What's your take on this promising new molecule in treatment of acne ?